The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
How to clean dirty bed pillows to leave them white and smelling sweet
Even with pillowcases, pillows gradually lose their freshness with time and may get stains. Every night, they come into contact with perspiration and other materials, which can result in dust, oil, or even microscopic mites. Keeping a clean pillow is crucial for allergy sufferers to get a good night’s sleep. You may create a healthy resting environment and learn how to clean your bed pillows with the aid of this tutorial.
Like picking sheets or duvets, choosing the correct pillow—feather-filled or latex, soft or firm—is essential to a restful night’s sleep. But regardless of its kind or caliber, maintaining cleanliness is essential. It is not protected from overnight sweating by a pillowcase alone, which can result in those unattractive yellow stains. Let’s look at some ways to revive your cushions and restore their former allure.
Continual Care for Pillows: How Often Should You Clean?
Cleaning your pillows on a regular basis is advised to prevent the yellow tinge. Sweat at night is the main cause of this discoloration, as it creates a moist environment that is perfect for germs and mites. Some people might throw away their pillows at the first sign of a stain, while others rely only on pillowcases to keep their furniture clean. The reality? Pillows should ideally be cleaned every six months. In the interim, launder your duvet once a year.
Pillow Revival: A Proven Cleaning Method
Are you looking for a quick and effective solution to kill bacteria and sanitize your pillows? Here’s a reliable, time-tested tip:
Components:
baking soda
Typical laundry detergent
Essential oil of lavender
Check the labels on your pillows to make sure they can be washed in a machine before you begin. After filling the selected drawer with your preferred detergent, add a half-cup of baking soda and a few drops of lavender oil straight into the drum. After running your wash, add two pillows for balance.
Make healthy everyday routines if you want to extend the freshness of your pillows. Take off the pillowcases, crack open the windows, and let the sun shine on your pillows every morning. This lets the air out of your room and keeps moisture and mold from growing. What if your pillows appear somewhat boring? A steam cleaning will make them look nicer. Before washing them in a machine, give them a quick soak in a solution of hydrogen peroxide, white vinegar, and lemon juice for a more vibrant look.
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