The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My granddaughter evicted me for getting married at 80 – Unable to tolerate the disrespect, I decided to teach her a lesson
When my granddaughter threw me out after I got married at 80, I decided I couldn’t condone the disrespect. With my new husband, Harold, we devised a daring plan to teach her a lesson she’ll never forget, leading to a confrontation that would change our family forever.
I never thought I’d be telling this story, but here we are. My name is Margaret, and I turned 80 last spring. I lived in a cozy room in my granddaughter Ashley’s house. It was small, but I made it my own — filled it with memories and mementos from my past life.
“Morning, Grandma,” Ashley said one bright Saturday, barging into my room without knocking. She never knocked.
“Morning, dear,” I replied, folding my quilt. “What’s the rush?”
“We’re heading out to the park with the kids. Need anything?
“No, I’m fine. Go enjoy your day.”
She left in a hurry, leaving me alone with my thoughts. I couldn’t complain much — after all, I had sold my house to pay for her college. Her parents died in a car crash when she was just 15.
I took her in and did my best to give her a good life. Now she lived here with her husband, Brian, and their two children. Their home was spacious, lively, and often noisy.
Life took an interesting turn at the community center a few months back. I met Harold. He was charming, with a camera slung around his neck. We started talking, and before I knew it, I was looking forward to our meetings. It was like a second chance at love.
One afternoon, while Ashley was at work, I decided to share my news. I found her in the kitchen later that evening, pouring over some recipe book.
“Ashley, I have something to tell you,” I began.
She glanced up, “What’s up, Grandma?”
“I’ve met someone. His name is Harold, and… well, he proposed.”
She stared at me, eyebrows raised. “Proposed? As in marriage?”
“Yes,” I said, unable to hide my smile. “Isn’t it wonderful?”
Her reaction wasn’t what I expected. “Grandma, you’re 80. You’re too old for a wedding dress and all that. And Harold can’t move in here.”
I was taken aback. “Why not? We have plenty of space.”
“This is our home. We need our privacy.”
I tried to reason with her, but she wouldn’t listen. The next morning, she packed my belongings and set them by the door.
“Ashley, what are you doing?” I asked, tears welling up.
“You need to go, Grandma. Find somewhere else to live. Maybe Harold can take you in.”
I couldn’t believe it. After everything I had done for her — raising her, selling my house — she was kicking me out. I felt so betrayed as I stood there, looking at the boxes of my life packed up like unwanted clutter.
I didn’t have many options, so I called Harold. When I told him what happened, he was furious.
“She did what?” he shouted. “Margaret, get your things together, I’m coming to fetch you right now. You’re coming to stay with me.”
I hesitated. “I don’t want to be a burden.”
“You’re not a burden. You’re my future wife, and we’re in this together.”
With no other choice, I loaded my things into Harold’s car. As we drove away, I looked back at Ashley’s house, my heart heavy with disappointment.
At Harold’s, things felt different. He welcomed me with open arms, making me feel at home. We spent our days planning our future, but the hurt from Ashley’s betrayal lingered.
“We’ll teach her a lesson,” Harold said one evening, determination in his eyes. “She needs to understand respect.”
I didn’t know how we’d do it, but I trusted Harold. He had a way of making everything seem possible.
“Alright,” I agreed. “Let’s show her what we’re made of.”
And so, the plan began.
Harold and I spent countless evenings planning our next move. Harold, being a renowned photographer, had an idea to reach Ashley through her passion. She loved photography, and the annual local photographer’s gathering was something she wouldn’t miss for the world.
“Margaret,” Harold said one night, “I’ve got a ticket for the gathering. Ashley won’t be able to resist — I’ll courier the ticket to her, anonymously.”
I nodded, feeling excited. “Let’s do it.”
Before the gathering, Harold and I got married in a small, intimate ceremony.
Harold insisted on taking photographs. He captured my happiness and the glow of a second chance at love. The photos were breathtaking, showing the joy in my eyes and the love between us.
The day of the photography event arrived, and Ashley, as predicted, attended. She didn’t know we were behind her invitation. Harold and I stood backstage, waiting for our moment. The anticipation was almost too much to bear, but we were determined to see it through.
The host called Harold on stage to present his award-winning photographs. As Harold walked out, the room buzzed with admiration. Then, the portraits of me in my wedding dress appeared on the big screen.
Gasps filled the room as the audience saw the radiant joy on my face. The images were stunning, capturing not just the beauty of the moment, but the depth of emotion behind it.
Harold stated: “I found love at 79, proving age is just a number. Margaret, my beautiful wife, has a youthful spirit and a heart full of love.”
I could see Ashley in the front row, her face turning red with embarrassment. Harold handed me the microphone, and I stepped forward, my heart pounding.
“Good evening,” I started. “I want to tell you about sacrifices and love. When my granddaughter, Ashley’s, parents died, I sold my house to pay for her education. I raised her as my own. But recently, she forgot that love and respect.”
The audience was silent, their attention on me. “Ashley,” I continued, looking directly at her, “I still love you despite the hurt. But you needed to learn the value of respect.”
Ashley’s eyes filled with tears. She looked down, clearly feeling the weight of her actions.
Harold then spoke again, “Margaret and I decided to share our story to show that love and respect know no age. Family should be about support and understanding.”
The audience burst into applause, admiration evident in throughout the hall. After the event, Ashley approached us, tears streaming down her face.
“Grandma, Harold,” she began, her voice shaking, “I’m so sorry. I was wrong and disrespectful. Can you ever forgive me?”
Harold and I shared a glance before I pulled Ashley into a hug. “Of course, dear. We love you. We just needed you to understand.”
She invited us to a family dinner, promising to support my happiness and never take me for granted again. We accepted, hopeful for a new beginning.
That evening, we joined Ashley and her family. The atmosphere was warm, filled with genuine attempts to rebuild our relationships. Laughter and conversation flowed easily, and for the first time in a long while, I felt truly at peace.
During dinner, Ashley turned to me. “Grandma, I didn’t realize how much I hurt you. I was selfish and ungrateful.”
“It’s okay, Ashley,” I said, placing my hand on hers. “What’s important is that we move forward together.”
Brian, Ashley’s husband, who had been mostly silent, chimed in: “We’re glad you’re happy, Margaret. Harold, you seem like a good man. We’re lucky to have you both in our lives.”
Harold smiled. “Thank you, Brian. We’re happy to be here.”
The children, sensing the positive change, started showing us their latest drawings and school projects. It was a joyous sight, a family coming together again. The warmth in the room was palpable, and I felt a renewed sense of belonging.
As the evening progressed, Harold shared more stories about our adventures and how we met. Ashley listened intently, occasionally wiping away tears. It was clear she was genuinely remorseful and wanted to make amends.
After dinner, as we sipped tea in the living room, Ashley turned to me again. “Grandma, I want you to move back in with us. We have plenty of space, and I promise things will be different.”
I looked at Harold, who nodded in agreement. “We appreciate the offer, Ashley, but Harold and I have our own place now. We’ll visit often, though.”
Ashley smiled, a bit sad but understanding. “I get it. I just want you to be happy.”
“I am happy,” I assured her. “And so are you. That’s all that matters.”
As we left that night, the moon casting a gentle glow over everything, I reflected on the importance of self-love and standing up for oneself. Life’s unexpected joys often come when we least expect them.
And as I looked around the table, I felt grateful for the second chance at happiness and the family that, despite everything, remained dear to my heart.
Harold and I drove home in silence, both lost in our thoughts. When we finally arrived, he took my hand and said, “We did it, Margaret. We really did it.”
I smiled, feeling a sense of accomplishment and relief. “Yes, we did. And it’s just the beginning.”
Harold kissed my hand, and we walked into our home, ready for whatever the future held. Our love and determination had taught Ashley a valuable lesson, and in turn, brought us all closer. It was a new chapter, filled with hope and endless possibilities.
What would you have done?
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